Drug interactions, dosage, and pregnancy and … Amlodipine Besylate is the besylate salt of amlodipine, a synthetic dihydropyridine with antihypertensive and antianginal effects. Follow your doctor's instructions very carefully. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Valsartan is an … Cerner Multum, Inc. "Australian Product Information." Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Copyright 1996-2021 Cerner Multum, Inc. Applies to amlodipine / valsartan: oral tablet, If pregnancy is confirmed, discontinue amlodipine valsartan immediately. Some side effects may not be reported. It is taken by mouth. High blood pressure often has no symptoms. Check with your physician for additional information about side effects. Norvasc side effects include headache and edema. AMLODIPINE; VALSARTAN is a combination of a calcium channel blocker and an angiotensin II receptor blocker. Store at room temperature away from moisture and heat. Cerner Multum, Inc. "UK Summary of Product Characteristics." Your reactions could be impaired. Amlodipine often gets a bad rap, but as you’ll see, the best meds can be those that have been used for decades. It treats high blood pressure. The lowest GoodRx price for the most common version of amlodipine / valsartan is around $39.23, 90% off the average retail price of $421.76. Amlodipine and valsartan can cause injury or death to the unborn baby if you take the medicine during your second or third trimester. Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Novartis Pharmaceuticals, East Hanover, NJ. Amlodipine-associated gingival overgrowth is a relatively common side effect with exposure to amlodipine. Common side effects include dizziness and headaches. Select one or more newsletters to continue. Follow all directions on your prescription label and read all medication guides or instruction sheets. If blood pressure remains uncontrolled after 3 to 4 weeks, may titrate up to a maximum of amlodipine 10 mg-valsartan 320 mg orally once a day. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. 2. An overview article by a cardiologist of the common and less common amlodipine side effects. Medically reviewed by Drugs.com on July 11, 2019. Blood pressure medication is only part of a complete treatment program that may also include diet, exercise, regular blood pressure checks, lifestyle changes, and other medications. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Stop using the medicine and tell your doctor right away if you become pregnant. [Ref], Very common (10% or more): BUN increased greater than 50% (up to 10.9%), Common (1% to 10%): Hypokalemia, serum potassium increased greater than 20%, Uncommon (0.1% to 1%): Anorexia, hypercalcemia, hyperlipidemia, hyperuricemia, hyponatremia, gout, non-insulin-dependent diabetes mellitus, hypercholesterolemia, Uncommon (0.1% to 1%): Weight increased, weight decreased, Very rare (less than 0.01%): Hyperglycemia, Frequency not reported: Serum potassium increased[Ref], Common (1% to 10%): Asthenia, fatigue, facial edema, edema, peripheral edema, pitting edema, Uncommon (0.1% to 1%): Ear pain, chest pain, pyrexia, Very common (10% or more): Peripheral edema (up to 10.3%), Common (1% to 10%): Fatigue, edema, ankle swelling, Uncommon (0.1% to 1%): Gynecomastia, asthenia, discomfort, malaise, non-cardiac chest pain, pain, Common (1% to 10%): Flushing, hot flush, orthostatic blood pressure decrease, Uncommon (0.1% to 1%): Palpitation, tachycardia, orthostatic hypotension, Common (1% to 10%): Palpitation, flushing, Very rare (less than 0.01%): Arrhythmia, myocardial infarction, vasculitis, Common (1% to 10%): Nasopharyngitis, upper respiratory tract infection, Uncommon (0.1% to 1%): Cough, pharyngolaryngeal pain, sinusitis, bronchitis, pharyngitis, pharyngotonsillitis, bronchitis acute, tonsillitis, sinus congestion, dyspnea, epistaxis, productive cough, dysphonia, nasal congestion, Uncommon (0.1% to 1%): Coordination abnormal, dizziness postural, paresthesia, somnolence, vertigo, sciatica, cervicobrachial syndrome, carpal tunnel syndrome, hypoesthesia, sinus headache, Common (1% to 10%): Dizziness, headache, somnolence, Uncommon (0.1% to 1%): Dysgeusia, paresthesia, syncope, tremor, hypoesthesia, tinnitus, Very rare (less than 0.01%): Hypertonia, peripheral neuropathy, neuropathy, Frequency not reported: Extrapyramidal syndrome, Common (1% to 10%): Creatine kinase increased greater than 300%, Uncommon (0.1% to 1%): Arthralgia, back pain, joint swelling, epicondylitis, joint sprain, limb injury, muscle spasm, pain in extremity, myalgia, osteoarthritis, musculoskeletal chest pain, Rare (less than 0.1%): Sensation of heaviness, Uncommon (0.1% to 1%): Arthralgia, back pain, muscle spasm, myalgia, Postmarketing reports: Rhabdomyolysis[Ref], Very rare (less than 0.01%): Hypersensitivity, Frequency not reported: Hypersensitivity[Ref], Common (1% to 10%): Creatinine increased greater than 50%, Frequency not reported: Serum creatinine increased, renal failure and impairment[Ref], Common (1% to 10%): ALT increased greater than 150%, Very rare (less than 0.01%): Liver function test abnormal, serum bilirubin increased, hepatitis, intrahepatic cholestasis, jaundice, Frequency not reported: Liver function test abnormal, serum bilirubin increased[Ref], Uncommon (0.1% to 1%): Abdominal discomfort, abdominal distention, abdominal pain, upper abdominal pain, constipation, diarrhea, dry mouth, nausea, dyspepsia, gastritis, vomiting, colitis, gastroenteritis, Common (1% to 10%): Abdominal discomfort, upper abdominal pain, nausea, Uncommon (0.1% to 1%): Change of bowel habit, diarrhea, dry mouth, dyspepsia, vomiting, Very rare (less than 0.01%): Gastritis, gingival hyperplasia, pancreatitis, Uncommon (0.1% to 1%): Abdominal discomfort, upper abdominal pain[Ref], Uncommon (0.1% to 1%): Erythema, rash, pruritus, hyperhidrosis, eczema, Uncommon (0.1% to 1%): Alopecia, exanthema, hyperhidrosis, photosensitivity reaction, pruritus, purpura, rash, skin discoloration, Very rare (less than 0.01%): Angioedema, erythema multiforme, urticaria, exfoliative dermatitis, Stevens-Johnson syndrome, Quincke edema, Frequency not reported: Angioedema, dermatitis bullous, pruritus, rash[Ref], Uncommon (0.1% to 1%): Hematuria, pollakiuria, erectile dysfunction, Uncommon (0.1% to 1%): Micturition disorder, nocturia, pollakiuria, impotence[Ref], Uncommon (0.1% to 1%): Insomnia, anxiety, depression, Uncommon (0.1% to 1%): Depression, insomnia/sleep disorders, mood swings, Rare (less than 0.1%): Visual disturbance, Uncommon (0.1% to 1%): Visual disturbance, visual impairment[Ref], Very rare (less than 0.01%): Leukopenia, thrombocytopenia, Frequency not reported: Hemoglobin decreased, hematocrit decreased, neutropenia, thrombocytopenia[Ref]. Find medical information, terminology and advice including side effects, drug interactions, user ratings and reviews, medication over dose, warnings and uses. Valsartan is an angiotensin II receptor antagonist. Written by Cerner Multum. Your blood pressure will need to be checked often. You may also need to avoid taking amlodipine and valsartan with aliskiren if you have kidney disease. Do not take two doses at one time. It is also used to treat certain types of angina (chest pain) and coronary artery disease (narrowing of the blood vessels that supply blood to the heart). Amlodipine is a calcium channel blocker (CCB). Do not use if you are pregnant. This is not a complete list of side effects and others may occur. Other important side effects are: hyperkalemia, impotence, reduced renal function, and; allergic reactions. Its empirical formula is C 24 H 29 N 5 O 3 and its molecular weight is 435.5.. Exforge tablets are formulated in 4 strengths for oral administration with a combination of amlodipine besylate, equivalent to 5 mg or 10 mg of amlodipine free-base, with 160 mg, or 320 mg of valsartan providing for the following available combinations: 5/160 mg, 10/160 mg, 5/320 mg, and 10/320 mg. This list is not complete and many other drugs may affect amlodipine and valsartan. You may take this medication with or without food. Use all medications as directed by your doctor. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. O 0. Rhabdomyolysis (inflammation and destruction of muscle) and angioedema (swelling of soft tissues including those of the throat and larynx) are rare but serious side effects of valsartan. I’m here to bust nine common myths of this useful medication. Call your doctor at once if you have: a light-headed feeling, like you might pass … Along with its needed effects, amlodipine / valsartan may cause some unwanted effects. It may take up to 4 weeks for this medication to control your blood pressure. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Last updated on Oct 8, 2020. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Do not use if you are pregnant. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: The most common adverse reactions were BUN increased greater than 50%, peripheral edema, nasopharyngitis, upper respiratory tract infection, and dizziness. Amlodipine and valsartan may also be used for purposes not listed in this medication guide. It causes relaxation and dilation of the blood vessels leading to lowering of blood pressure. You should not breastfeed while using this medicine. Although not all of these side effects may occur, if they do occur they may need medical attention. Call your doctor for medical advice about side effects. amlodipine, metoprolol, lisinopril, losartan, furosemide, hydrochlorothiazide. Generic Name: amlodipine and valsartan (am LOE de peen val SAR tan)Brand Name: ExforgeDosage Forms: oral tablet (10 mg-160 mg; 10 mg-320 mg; 5 mg-160 mg; 5 mg-320 mg). Many drugs can affect amlodipine and valsartan, especially: simvastatin or other cholesterol medication; heart or blood pressure medication, including a diuretic ("water pill"); or. O 0, 3. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Injury and death to the developing fetus may result from drugs that act directly on the renin-angiotensin system. Exforge (amlodipine-valsartan)." Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective. If you have diabetes, do not use amlodipine and valsartan together with any medication that contains aliskiren (a blood pressure medicine). a light-headed feeling, like you might pass out; swelling in your hands or feet, rapid weight gain; or. Not all possible drug interactions are listed here. Lowering blood pressure may lower your risk of a stroke or heart attack. Medically reviewed by Drugs.com. Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Amlodipine Side Effects What To Expect. Use the medicine exactly as directed. Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not use potassium supplements or salt substitutes, unless your doctor has told you to. Postmarketing side effects of amlodipine reported include: Extrapyramidal disorder (muscle spasms, restlessness, muscle rigidity, slow movement, tremor, and jerky movements) This document does not contain all possible side effects and others may occur. Along with its needed effects, amlodipine / valsartan may cause some unwanted effects. The recall does not currently include the brand name valsartan-containing drugs Diovan, Entresto, Exforge, and Exforge HCT. With valsartan and losartan recently recalled due to contamination, patients have been asking about other options for blood pressure control. Keep using amlodipine and valsartan as directed, even if you feel well. Your doctor may occasionally change your dose. Amlodipine / valsartan systemic 5 mg / 160 mg (p 574). You may need to use blood pressure medicine for the rest of your life. Amlodipine (Norvasc) is a calcium channel blocker drug prescribed for the treatment of high blood pressure and the treatment and prevention of chest pain caused by angina. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Side effects requiring immediate medical attention. Available for Android and iOS devices. Amlodipine/valsartan (Exforge) is an oral medication used to treat hypertension (high blood pressure). Amlodipine and valsartan is usually given after other blood pressure medicines have been tried without success. The valsartan recall includes several, but not all, generic drugs that contain valsartan as the active ingredient. You should not use this medicine if you are allergic to amlodipine (Norvasc) or valsartan (Diovan). Call your doctor if you are sick with vomiting or diarrhea, or if you are sweating more than usual. Your kidney function may also need to be checked. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Amlodipine and valsartan side effects. Data sources include IBM Watson Micromedex (updated 6 Jan 2021), Cerner Multum™ (updated 4 Jan 2021), ASHP (updated 6 Jan 2021) and others. Amlodipine is a calcium channel blocker. cold symptoms such as stuffy nose, sneezing, sore throat. Although not all of these side effects may occur, if they do occur they may need medical attention. 1) Amlodipine is bad for your heart. Avoid driving or hazardous activity until you know how this medicine will affect you. As a result, amlodipine relaxes the blood vessels and increases the supply of blood and oxygen to the heart while reducing its workload. We comply with the HONcode standard for trustworthy health information -, Drug class: angiotensin II inhibitors with calcium channel blockers, Angiotensin II inhibitors with calcium channel blockers. "Product Information. Amlodipine inhibits the influx of extracellular calcium ions into myocardial and peripheral vascular smooth muscle cells, thereby preventing vascular and myocardial contraction. You may report them to the FDA. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Initial therapy: Amlodipine 5 mg-Valsartan 160 mg orally once a dayAdd-on/Replacement therapy: Amlodipine 5 to 10 mg-Valsartan 160 to 320 mg orally once a dayComments:-May increase dose after 1 to 2 weeks of therapy.-A patient who experiences dose-limiting adverse reactions on either component alone may be switched to this drug containing a lower dose of that component in combination with the other. NSAIDs (nonsteroidal anti-inflammatory drugs)--aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), and others. Drinking alcohol with amlodipine and valsartan can cause side effects. Version: 10.01. amlodipine, metoprolol, lisinopril, losartan, furosemide, hydrochlorothiazide. 1. Available for Android and iOS devices. Sometimes it is not safe to use certain medications at the same time. These side effects may go away during treatment as your body adjusts to the medicine. Amlodipine is used alone or in combination with other medications to treat high blood pressure in adults and children 6 years and older. Side effects occurring less than 1% of the time include: blood disorders, impotence, depression, peripheral neuropathy, insomnia, tachycardia, gingival enlargement, hepatitis, and jaundice. Amlodipine / valsartan systemic 5 mg / 160 mg (p 574), We comply with the HONcode standard for trustworthy health information -, Drug class: angiotensin II inhibitors with calcium channel blockers, Angiotensin II inhibitors with calcium channel blockers, dizziness, faintness, or lightheadedness when getting up from a lying or sitting position, fast, irregular, pounding, or racing heartbeat or pulse, pain or tenderness around the eyes and cheekbones, swelling of the eyelids, face, lips, hands, or feet, continuing ringing or buzzing or other unexplained noise in the ears, difficulty having a bowel movement (stool), itching, pain, redness, or swelling of the eye or eyelid, loss in sexual ability, desire, drive, or performance, swelling of the abdominal or stomach area. Check with your doctor immediately if any of the following side effects occur while taking amlodipine / valsartan: Get emergency help immediately if any of the following symptoms of overdose occur while taking amlodipine / valsartan: Some side effects of amlodipine / valsartan may occur that usually do not need medical attention. Learn about side effects, warnings, dosage, and more. Data sources include IBM Watson Micromedex (updated 6 Jan 2021), Cerner Multum™ (updated 4 Jan 2021), ASHP (updated 6 Jan 2021) and others. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Find patient medical information for Amlodipine-Valsartan Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Tell your doctor about all your current medicines. The most likely reason to be started on amlodipine is for blood pressure control. It is a combination of valsartan, an angiotensin receptor blocker with hydrochlorothiazide, a diuretic. Amlodipine and valsartan is a combination medicine used to treat high blood pressure (hypertension). Valsartan/hydrochlorothiazide, sold under the brand name Diovan HCT among others, is an medication used to treat high blood pressure when valsartan is not sufficient. You may report side effects to FDA at 1-800-FDA-1088. It affects the movement of calcium into the cells of the heart and blood vessels. If you need surgery, tell the surgeon ahead of time that you are using amlodipine and valsartan. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Amlodipine and valsartan is not approved for use by anyone younger than 18 years old. You may have very low blood pressure while taking this medication. If you become pregnant, stop taking amlodipine and valsartan and tell your doctor right away. high potassium level--nausea, weakness, tingly feeling, chest pain, irregular heartbeats, loss of movement. Do not change your doses or stop taking any of your medications without your doctor's advice. Aliskiren if you feel well personal medication records, an angiotensin receptor with... And tell your doctor 's advice and death to the heart while its! Stroke or heart attack for the rest of your medications without your doctor right away myocardial and peripheral smooth... Certain medications at the same time other medications to treat high blood pressure medicine the! Of the heart while reducing its workload ( high blood pressure will need to be checked often from moisture heat. Only amlodipine / valsartan side effects is not intended for medical advice, diagnosis or treatment your provider!, alerts and updates weight gain ; or not use this medicine affect... 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And increases the supply of blood and oxygen to the unborn baby if you need surgery tell! A blood pressure chest pain, irregular heartbeats, loss of movement drugs you take, may! Multum, Inc. `` UK Summary of Product Characteristics. or death to the unborn baby if you:! The influx of extracellular calcium ions into myocardial and peripheral vascular smooth muscle cells, thereby preventing vascular and contraction. Oxygen to the developing fetus may result from drugs that act directly on the renin-angiotensin system medicine during your or! Feeling, like you might pass out ; swelling in your hands or feet, rapid weight ;! Amlodipine / valsartan: oral tablet, if they do occur they may need to be started on is.